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Observe Carefully (1)phenobarbital will lower the level or effect of fentanyl transmucosal by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Check Intently. Coadministration of fentanyl with CYP3A4 inducers may lead to your lower in fentanyl plasma concentrations, insufficient efficacy or, perhaps, improvement of a withdraw

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